Visit of the CNRS Chemistry Ambassador: Wonwoo Nam

PROGRAM

9am Welcome by Carole Duboc

9:15 Pascale Delangle (SyMMES)

How to mimic metal binding sites in biology using peptide design approaches?

9:40 Alan Le Goff (DCM)

Oxidative and Reductive Electrocatalysis by Carbon-nanotube-supported Cuproenzymes and Models

10:05 Marie-Noëlle Collomb (DCM)

Bio-Inspired Polymer/Metal Oxide Nanocomposites for Efficient Water Oxidation

10:30 Coffee break

10:55 Matthieu Koepf (LCBM)

Electrodriven nitrogen activation : bioinspired and non-bioinspired approaches

11:20 Wonwoo Nam (Ewha Womans University, Korea)

Biomimetic Metal-Oxygen Intermediates in Dioxygen Activation and Formation Reactions

Dioxygen is essential in life processes, and enzymes activate dioxygen to carry out a variety of biological reactions. One primary goal in biomimetic research is to elucidate structures of reactive intermediates and mechanistic details of dioxygen activation and formation reactions occurring at the active sites of enzymes, by utilizing synthetic metal-oxygen complexes. A growing class of metal-oxygen complexes, such as metal–superoxo, –peroxo, –hydroperoxo, and –oxo species, have been isolated, characterized spectroscopically, and investigated in various oxygenation reactions. During the past several decades, we have been studying the chemical and physical properties of various reactive intermediates, such as high-valent iron- and manganese-oxo complexes of heme and non-heme ligands in oxo-transfer and C-H activation reactions, non-heme metal-peroxo complexes in nucleophilic reactions, and non-heme metal-superoxo complexes in electrophilic reactions. The effects of supporting and axial ligands on structural and spectroscopic properties and reactivities of metal-oxygen adducts have been extensively investigated as well. In this seminar, I will present our recent results on the synthesis and structural and spectroscopic characterization of mononuclear nonheme metal-dioxygen intermediates as well as their reactivities in electrophilic and nucleophilic oxidation reactions.  

General References

1.    Xue-Peng Zhang, Anirban Chandra, Yong-Min Lee, Rui Cao, Kallol Ray, and Wonwoo Nam “Transition Metal-Mediated O–O Bond Formation and Activation in Chemistry and Biology” Chem. Soc. Rev. 2021, 58, 4804–4811

2.    Virginia Larson, Beatrice Battistella, Kallol Ray, Nicolai Lehnert, and Wonwoo Nam “Iron and Manganese Oxo Complexes, Oxo Wall and Beyond” Nature Reviews Chemistry 2020, 4, 404–419.

3.    Shunichi Fukuzumi, Kyung-Bin Cho, Yong-Min Lee, Seungwoo Hong, and Wonwoo Nam “Mechanistic Dichotomies in Redox Reactions of Mononuclear Metal-Oxygen Intermediates” Chem. Soc. Rev. 2020, 49, 8988–19027.

4.    Wonwoo Nam “Hydrogen Atom Transfer Reactions by Metal-Oxygen Intermediates” Acc. Chem. Res. 2018, 51, 2014–2022. 

5.    Kyung-Bin Cho, Hajime Hirao, Sason Shaik, and Wonwoo Nam “To rebound or dissociate? This is the mechanistic question in C-H hydroxylation by heme and nonheme metal-oxo complexes” Chem. Soc. Rev. 2016, 45, 1197–1210.

6.    Wonwoo Nam “Synthetic Mononuclear Nonheme Iron-Oxygen Intermediates” Acc. Chem. Res. 2015, 48, 2415–2423.

7.    Wonwoo Nam, Yong-Min Lee, and Shunichi Fukuzumi “Tuning Reactivity and Mechanism in Oxidation Reactions by Mononuclear Nonheme Iron(IV)-Oxo Complexes” Acc. Chem. Res. 2014, 47, 1146–1154.

8.    Jaeheung Cho, Ritimukta Sarangi, and Wonwoo Nam “Mononuclear Metal-O₂ Complexes Bearing Macrocyclic TMC Ligands Acc. Chem. Res. 2012, 45, 1321–1330.

9.    Wonwoo Nam “High-Valent Iron(IV)-Oxo Complexes of Heme and Nonheme Ligands in Oxygenation Reactions” Acc. Chem. Res. 2007, 40, 522–531.

10.  Wonwoo Nam “Guest Editorial: Dioxygen Activation by Metalloenzymes and Models” Acc. Chem. Res. 2007, 40, 465.

12:30 Lunch