The ARCANE labex brings together all of Grenoble's research laboratories for which molecular chemistry constitutes the heart of their research activity. As such, and by its multi-supervisory nature, it is a key element of local coordination in chemistry training. The calls for projects are addressed to the 7 labex laboratories. One of the main selection criteria is the synergy effect that an inter-laboratory collaboration can bring. The listed projects are fully or partially funded by the ARCANE labex.

  • SelDNP enhanced solid-state NMR is a targeted DNP methodology that aims to recover site-specific information in the vicinity of the paramagnetic moieties to decipher proteins binding sites at high resolution.
  • My work consists in designing molecular structures capable of producing hydrogen from water using sunlight as sole energy source.
  • Synthesis of new glycomimetics able to selectively recognize alpha glucosidases (enzymes) in complexe biological media.
  • Development of biomimetic and stealth nanoparticles for biomedical applications. As a proof of concept, Glypidots will be assessed for their ability to inhibit Influenza virus infection.
  • Liquid biopsy appears like a promising way for the early detection of cancers. The PhD project aims to the development of a microfluidic device for the bio-targeting sorting of extracellular vesicles.
  • Synthesis of redox active complexes as contrast agents for the detection of reactive oxygen species.
  • In this project, we propose to combine enzymatic electrochemical biosensor technology with biopolymer-microneedle sampling for rapid metabolite detection for medical applications.
  • We propose a new approach to improve the selectivity of aptamers: to form covalent crosslinks between them and their target molecule.
  • This multidisciplinary project aims to rationally design inhibitors of NDM-1, an enzyme responsible for bacterial resistance by β-lactam antibiotic hydrolysis.
  • Design of small antibody mimics of the Rituximab using a fully synthetic approach combining aptamers and peptides.
  • Assembly of a Gold Nano Rod with Quantum Dots using DNA to create a new versatile and multi-modal biomarker.
  • Synthesis of an unprecedented scale of small molecules to identify biologically active compounds targeting G-quadruplexe, a DNA secondary structure.
  • To find alternative to syngas upgrade, our approach is the development of enzymatic water-gas shift reaction via the immobilisation of CODH and [NiFe]-hydrogenase on carbon-nanotubes.