PhD Program

Constructing new catalytic films to enhance enzymatic reactions thanks to a biosourced and electron-conducting matrix

Rapid kit which detects a pathogenic Escherichia coli strain with aptamers and then quantify them through ATP measurement.

My work is to improve and develop responsive probes based on an Eu3+ complex featuring a carbazole antenna imaging agent.

My work is on the theoretical study of the reduction mechanism of CO2catalyzed by Ni-Fe complex on graphite layer.

My project is to develop a new reactivity by combining catalytic systems to make selective sulfoxidation synthesis.

Development of a new detection method for small analytes involving aptamers and the formation of fluorescent indolizines via a DNA-templated 1,3-dipolar cycloaddition.

Synthesis of hemiindigos (HI) and hemithioindigos (HTI) able to selectively engage human tyrosinase upon photoisomerization under visible light.

Synthesis, surface-functionalisation and in-vitro stability of new non-toxic quantum dots as novel biomedical probes for theranostic applications.

SelDNP enhanced solid-state NMR is a targeted DNP methodology that aims to recover site-specific information in the vicinity of the paramagnetic moieties to decipher proteins binding sites at high resolution.

My work consists in designing molecular structures capable of producing hydrogen from water using sunlight as sole energy source.

Synthesis of new glycomimetics able to selectively recognize alpha glucosidases (enzymes) in complexe biological media.

Development of biomimetic and stealth nanoparticles for biomedical applications. As a proof of concept, Glypidots will be assessed for their ability to inhibit Influenza virus infection.

Liquid biopsy appears like a promising way for the early detection of cancers. The PhD project aims to the development of a microfluidic device for the bio-targeting sorting of extracellular vesicles.

Synthesis of redox active complexes as contrast agents for the detection of reactive oxygen species.

In this project, we propose to combine enzymatic electrochemical biosensor technology with biopolymer-microneedle sampling for rapid metabolite detection for medical applications.

We propose a new approach to improve the selectivity of aptamers: to form covalent crosslinks between them and their target molecule.

This multidisciplinary project aims to rationally design inhibitors of NDM-1, an enzyme responsible for bacterial resistance by β-lactam antibiotic hydrolysis.

Design of small antibody mimics of the Rituximab using a fully synthetic approach combining aptamers and peptides.

Assembly of a Gold Nano Rod with Quantum Dots using DNA to create a new versatile and multi-modal biomarker.

Synthesis of an unprecedented scale of small molecules to identify biologically active compounds targeting G-quadruplexe, a DNA secondary structure.

To find alternative to syngas upgrade, our approach is the development of enzymatic water-gas shift reaction via the immobilisation of CODH and [NiFe]-hydrogenase on carbon-nanotubes.