The ARCANE labex brings together all of Grenoble's research laboratories for which molecular chemistry constitutes the heart of their research activity. As such, and by its multi-supervisory nature, it is a key element of local coordination in chemistry training. The calls for projects are addressed to the 7 labex laboratories. One of the main selection criteria is the synergy effect that an inter-laboratory collaboration can bring. The listed projects are fully or partially funded by the ARCANE labex.
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Rapid kit which detects a pathogenic Escherichia coli strain with aptamers and then quantify them through ATP measurement. -
My work is to improve and develop responsive probes based on an Eu3+ complex featuring a carbazole antenna imaging agent. -
My work is on the theoretical study of the reduction mechanism of CO2catalyzed by Ni-Fe complex on graphite layer. -
My project is to develop a new reactivity by combining catalytic systems to make selective sulfoxidation synthesis. -
Development of a new detection method for small analytes involving aptamers and the formation of fluorescent indolizines via a DNA-templated 1,3-dipolar cycloaddition. -
Synthesis of hemiindigos (HI) and hemithioindigos (HTI) able to selectively engage human tyrosinase upon photoisomerization under visible light. -
Synthesis, surface-functionalisation and in-vitro stability of new non-toxic quantum dots as novel biomedical probes for theranostic applications. -
SelDNP enhanced solid-state NMR is a targeted DNP methodology that aims to recover site-specific information in the vicinity of the paramagnetic moieties to decipher proteins binding sites at high resolution. -
My work consists in designing molecular structures capable of producing hydrogen from water using sunlight as sole energy source. -
Synthesis of new glycomimetics able to selectively recognize alpha glucosidases (enzymes) in complexe biological media. -
Development of biomimetic and stealth nanoparticles for biomedical applications. As a proof of concept, Glypidots will be assessed for their ability to inhibit Influenza virus infection. -
Liquid biopsy appears like a promising way for the early detection of cancers. The PhD project aims to the development of a microfluidic device for the bio-targeting sorting of extracellular vesicles. -
Synthesis of redox active complexes as contrast agents for the detection of reactive oxygen species. -
In this project, we propose to combine enzymatic electrochemical biosensor technology with biopolymer-microneedle sampling for rapid metabolite detection for medical applications. -
We propose a new approach to improve the selectivity of aptamers: to form covalent crosslinks between them and their target molecule. -
This multidisciplinary project aims to rationally design inhibitors of NDM-1, an enzyme responsible for bacterial resistance by β-lactam antibiotic hydrolysis. -
Design of small antibody mimics of the Rituximab using a fully synthetic approach combining aptamers and peptides. -
Assembly of a Gold Nano Rod with Quantum Dots using DNA to create a new versatile and multi-modal biomarker. -
Synthesis of an unprecedented scale of small molecules to identify biologically active compounds targeting G-quadruplexe, a DNA secondary structure. -
To find alternative to syngas upgrade, our approach is the development of enzymatic water-gas shift reaction via the immobilisation of CODH and [NiFe]-hydrogenase on carbon-nanotubes.