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You are hereHomeResearch & InnovationHIGHLIGHTS

Highlights

  • Hijacking the Peptidoglycan Recycling Pathway of Escherichia coli to Produce Muropeptides
    Muropeptides are short peptidoglycan fragments released from the cell wall of bacteria as part of their metabolism or as a result of biological stresses. These compounds trigger immune responses in mammals and plants. In...
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  • Details of protein-carbohydrate interactions revealed by neutron crystallography
    In view of the threat to human health caused by bacterial antibiotic resistance, new strategy, such as anti-infectious compounds, are of high interest. Pseudomonas aeruginosa, a major cause of nosocomial infections, uses...
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  • DEVELOPMENT OF A SIZE-BASED SORTING AND BIOMARKER-SPECIFIC MICROFLUIDIC SYSTEM FOR THE ANALYSIS OF EXTRACELLULAR VESICLES
    Extracellular Vesicles (EVs) are nanoscale lipid particles secreted by cells and actively participating to intercellular communication. They have received increasing attention over the past decade as non-invasive biomark...
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  • Efficient enzymatic CO2 reduction reaction on carbon nanotubes.
    An original 1-acetato-4-(1-pyrenyl)-1,4,7-tria- zacyclononane (AcPyTACN) was synthesized for the immobilization of a His-tagged recombinant CODH from Rhodospirillum rubrum (RrCODH) on carbon-nanotube electrodes. The stro...
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  • Highly efficient polarizing agents for MAS-DNP of proton-dense molecular solids
    Efficiently hyperpolarizing proton-dense molecular solids through dynamic nuclear polarization solid-state NMR is still an unmet challenge. Polarizing agents (PAs) developed so far do not perform well on proton-rich syst...
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  • Biomolecular and Biological Applications of Solid-State NMR with Dynamic Nuclear Polarization Enhancement
    Solid-state NMR enables the investigation of biological systems within their native context, e.g. lipid membranes, viral capsid assemblies, and cells. However, such investigations often suffer from low sensitivity due to...
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  • A fluorescent probe to investigate uranyl-protein interactions
    Uranium is naturally present in the environment as the dioxo cation uranyl. Understanding its interaction with proteins is key to decipher the mechanisms underlying its toxicity and to develop decorporation strategies. I...
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  • Experiments and DFT Computations Combine to Decipher Fe- Catalyzed Amidine Synthesis through Nitrene Transfer and Nitrile Insertion
    The development of multicomponent reactions (MCR) is the prefered eco-compatible approach to sophisticated molecules of pharmaceutical interest, such as amidines. We elaborated a new MCR to amidines which produces them i...
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  • Aptamer-based biosensors using quencher metal ions
    We describe an aptamer-based sensing approach that signals the presence of small-molecule targets when fluorescent DNA probes are challenged with the Ni2+ or Co2+ quencher metal ions. Functional oligonucleotides targetin...
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  • Optical Bacteriophage Susceptibility Screening by Surface Plasmon Resonance
    The proliferation of multiresistant bacteria is having an increasing and profound impact on the world. A credible alternative to antibiotics is bacteriophage therapy, which are expected in the near future to form the bas...
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  • Self-Assembly of a Ginkgo Oligomerization Domain Creates a Sub-10-nm Honeycomb Architecture on Carbon and Silicon Surfaces with Customizable Pores: Implications for Nanoelectronics, Biosensing, and Biocatalysis
    Surface nanopatterning with self-assembled molecules has gained in interest over the last years because of its usefullness in nanotechnology. In here, the natural abilities of a protein to self-assemble in a honeycomb st...
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  • Asymmetric Intramolecular Buchner Reaction
    Bicyclic compounds bearing a quaternary stereogenic center have been obtained using asymmetric intramolecular Buchner reaction with excellent yields and level of enantioselectivity. X-ray crystallography determination of...
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  • Efficient Electrochemical CO2/CO Interconversion by an Engineered Carbon Monoxide Dehydrogenase on a Gas-Diffusion Carbon Nanotube-Based Bioelectrode
    We have developed an enzymatic process that achieves high performance towards the reversible electrochemical CO2-to-CO conversion under mild conditions with low overvoltage. Using an engineered Carbon Monoxide Dehydrogen...
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  • Repurposing a Bio-Inspired NiFe Hydrogenase Model for CO2Reduction with Selective Production of Methane as the Unique C-Based Product
    This publication reports the unprecedented reactivity of a molecular electrocatalyst physiadsorbed on a graphite electrode: a bioinspired Ni(II)Fe(II) complex selectively and catalytically reduces CO2 in acidic aqueous s...
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  • Targeted DNP for biomolecular solid-state NM
    In targeted DNP, polarizing agents are localized at specific sites of the biomolecular system allowing the development of NMR approaches to improve sensitivity, background suppression for in-cell NMR, access to long-rang...
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  • Impact of ionomer structuration on the performance of bio-inspired noble- metal-free fuel cell anodes
    The ecological transition requires cheap and abundant electrocatalysts to achieve six key reactions: H2 evolution (HER), H2 oxidation (HOR), CO2 reduction (CO2RR), N2 reduction (NRR), O2 evolution (OER), and O2 reduction...
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  • Polysaccharides with supramolecular “glycosylations” as adaptive glycomaterials
    In collaboration between two teams of Grenoble, CERMAV & SyMMES, and a Finnish team (Aalto University – Prof. Olli IKKALA), the first ever built linear supramolecular polysaccharide has been obtained. This proof-of-con...
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