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Muropeptides are short peptidoglycan fragments released from the cell wall of bacteria as part of their metabolism or as a result of biological stresses. These compounds trigger immune responses in mammals and plants. In... -
In view of the threat to human health caused by bacterial antibiotic resistance, new strategy, such as anti-infectious compounds, are of high interest. Pseudomonas aeruginosa, a major cause of nosocomial infections, uses... -
Extracellular Vesicles (EVs) are nanoscale lipid particles secreted by cells and actively participating to intercellular communication. They have received increasing attention over the past decade as non-invasive biomark... -
An original 1-acetato-4-(1-pyrenyl)-1,4,7-tria- zacyclononane (AcPyTACN) was synthesized for the immobilization of a His-tagged recombinant CODH from Rhodospirillum rubrum (RrCODH) on carbon-nanotube electrodes. The stro... -
Efficiently hyperpolarizing proton-dense molecular solids through dynamic nuclear polarization solid-state NMR is still an unmet challenge. Polarizing agents (PAs) developed so far do not perform well on proton-rich syst... -
Solid-state NMR enables the investigation of biological systems within their native context, e.g. lipid membranes, viral capsid assemblies, and cells. However, such investigations often suffer from low sensitivity due to... -
Uranium is naturally present in the environment as the dioxo cation uranyl. Understanding its interaction with proteins is key to decipher the mechanisms underlying its toxicity and to develop decorporation strategies. I... -
The development of multicomponent reactions (MCR) is the prefered eco-compatible approach to sophisticated molecules of pharmaceutical interest, such as amidines. We elaborated a new MCR to amidines which produces them i... -
We describe an aptamer-based sensing approach that signals the presence of small-molecule targets when fluorescent DNA probes are challenged with the Ni2+ or Co2+ quencher metal ions. Functional oligonucleotides targetin... -
The proliferation of multiresistant bacteria is having an increasing and profound impact on the world. A credible alternative to antibiotics is bacteriophage therapy, which are expected in the near future to form the bas... -
Surface nanopatterning with self-assembled molecules has gained in interest over the last years because of its usefullness in nanotechnology. In here, the natural abilities of a protein to self-assemble in a honeycomb st... -
Bicyclic compounds bearing a quaternary stereogenic center have been obtained using asymmetric intramolecular Buchner reaction with excellent yields and level of enantioselectivity. X-ray crystallography determination of... -
We have developed an enzymatic process that achieves high performance towards the reversible electrochemical CO2-to-CO conversion under mild conditions with low overvoltage. Using an engineered Carbon Monoxide Dehydrogen... -
This publication reports the unprecedented reactivity of a molecular electrocatalyst physiadsorbed on a graphite electrode: a bioinspired Ni(II)Fe(II) complex selectively and catalytically reduces CO2 in acidic aqueous s... -
In targeted DNP, polarizing agents are localized at specific sites of the biomolecular system allowing the development of NMR approaches to improve sensitivity, background suppression for in-cell NMR, access to long-rang... -
The ecological transition requires cheap and abundant electrocatalysts to achieve six key reactions: H2 evolution (HER), H2 oxidation (HOR), CO2 reduction (CO2RR), N2 reduction (NRR), O2 evolution (OER), and O2 reduction... -
In collaboration between two teams of Grenoble, CERMAV & SyMMES, and a Finnish team (Aalto University – Prof. Olli IKKALA), the first ever built linear supramolecular polysaccharide has been obtained. This proof-of-con...
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