Development of combinatorial encoded chemistry for the identification of specific ligands of G-quadruplex DNA structures
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Synthesis of an unprecedented scale of small molecules to identify biologically active compounds targeting G-quadruplexe, a DNA secondary structure.
With training in organic chemistry applied to biological system in the University of Strasbourg, I joined the Molecular Chemistry Department (DCM) of Grenoble in a group specialized in the synthesis of oligonucleotide conjugates and their applications. Focused on the bioorganic chemistry of nucleic acids, offering a strong expertise in peptidic chemistry and biophysical interaction, I decided to join the group for its multidisciplinary knowledge. The project I applied for is also in collaboration with the Molecular Pharmacochemistry Department (DPM) of Grenoble, specialized in organic and medicinal chemistry.
To summarize, my PhD project permit me to valorize strong knowledge in biomolecular chemistry but also in (bio-)organic chemistry, in a multidisciplinary environment.
After my doctoral degree I will probably look for new opportunities either in enterprises or in academic areas of biomolecular chemistry or related fields.
To summarize, my PhD project permit me to valorize strong knowledge in biomolecular chemistry but also in (bio-)organic chemistry, in a multidisciplinary environment.
After my doctoral degree I will probably look for new opportunities either in enterprises or in academic areas of biomolecular chemistry or related fields.
Thesis dates
Beginning: 2018
End: 2021
End: 2021
Supervisors
Thomas Lavergne (DCM), Isabelle Baussanne and Martine Demeunynck (DPM)
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