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Letícia M. Lazinski

Synthesis of Hemiindigoids as Photoswitchable Entities: a Spatiotemporal Handling of Inhibition for Tyrosinase

Synthesis of hemiindigos (HI) and hemithioindigos (HTI) able to selectively engage human tyrosinase upon photoisomerization under visible light.

I am Letícia, a first year PhD student working on a collaborative project between the DPM and the DCM. My main motivations concerning this project are its originality and the possibility of developing potential molecules for photopharmacological and medicinal applications. Being a pharmacist with a master’s degree in chemistry, this PhD allows me to work with my favorite fields (medicinal chemistry, organic chemistry and analytical chemistry) and to learn new techniques in photochemistry and photophysics. It is also an opportunity to perform new studies on the behaviour of HI and HTI photoswitches for biological systems, as they are rather unexplored in this field.
Besides the opportunity to work at the interface between chemistry and biology, the Labex-Arcane fellowship allows me to develop cross-disciplinary skills and techniques linked to the specific expertise of the laboratories involved in this project.
After the PhD, my aim is to work with research in the pharmaceutical industry.
 

Thesis dates

Beginning: 2021
End: 2024

Supervisors

Romain Haudecoeur (DPM) and Guy Royal (DCM)

Submitted on October 21, 2021

Updated on October 21, 2021