Improving selective DNP (SelDNP) for the study of protein binding sites
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SelDNP enhanced solid-state NMR is a targeted DNP methodology that aims to recover site-specific information in the vicinity of the paramagnetic moieties to decipher proteins binding sites at high resolution.
I received my Master in Integrated Structural Biology, funded by IDEX, in 2019 from the University Grenoble Alpes, France. I performed my master internship in biomolecular liquid-state NMR at IRIGIBS under the supervision of Drs. Beate Bersch and Paul Schanda. I am currently a PhD student, funded by labex ARCANE, at IRIG-MEM and CERMAV under the supervision of Drs. Sabine Hediger, Gaël De Paëpe and Anne Imberty, working on improving the SelDNP methodology for the study of protein binding sites.
SelDNP project is “original” since it aims at developing a novel and robust approach to access atomic scale information of protein binding site, where the samples preparation and the data acquisition require a lot of work including chemical, biochemical and spectroscopic optimizations.
SelDNP project is relevant regarding ARCANE’s objectives scope as it includes a bio-targeted chemistry as a tool to highlight carbohydrate binding sites on lectines using an advanced DNP-based approach.
After the completion of my PhD, I want to pursue postdoctoral research followed by a career in academics.
SelDNP project is “original” since it aims at developing a novel and robust approach to access atomic scale information of protein binding site, where the samples preparation and the data acquisition require a lot of work including chemical, biochemical and spectroscopic optimizations.
SelDNP project is relevant regarding ARCANE’s objectives scope as it includes a bio-targeted chemistry as a tool to highlight carbohydrate binding sites on lectines using an advanced DNP-based approach.
After the completion of my PhD, I want to pursue postdoctoral research followed by a career in academics.
Thesis dates
Beginning: 2019
End: 2023
End: 2023
Supervisors
Drs. Sabine Hediger, Gaël De Paëpe (IRIG-MEM, CEA) and Anne Imberty (GBMs-CERMAV, CNRS)
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