Glycoengineering Nanostructured Lipid Carriers via Grafting or Anchoring: a comparative study

Nanostructured lipid carriers (NLCs) have emerged as a promising platform for drug delivery, offering advantages such as high drug-loading capacity and improved physicochemical stability. To enhance their targeting specificity, surface functionalization is crucial, as it enables selective interactions with biological receptors. In this study, we evaluated two distinct chemical strategies for the glycoengineering of NLCs. The grafting method proved superior, yielding glycosylated NLCs that were stable, biocompatible, and efficiently functionalized.