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Highly efficient polarizing agents for MAS-DNP of proton-dense molecular solids

MEM

Efficiently hyperpolarizing proton-dense molecular solids through dynamic nuclear polarization solid-state NMR is still an unmet challenge. Polarizing agents (PAs) developed so far do not perform well on proton-rich systems, such as organic microcrystals and biomolecular assemblies. In this paper, we introduce a new PA, cAsymPol-POK, and report outstanding hyperpolarization efficiency on a protein and pharmaceutical drugs at high magnetic fields and fast magic angle spinning frequencies.

Highly efficient Polarizing Agents for MAS-DNP of proton-dense molecular solids, R. Harrabi, T. Halbritter, F. Aussenac, O. Dakhlaoui, J. van Tol, K. K. Damodara, D. Lee, S. Paul, S. Hediger, F. Mentin-Vigier, S. Th. Sigurdsson, G. De Paëpe, Angew. Chem. Intl. Ed., 2022, 61, e202114103. DOI: 10.1002/anie.202114103.
 

Submitted on December 21, 2022

Updated on December 21, 2022