Muropeptides are short peptidoglycan fragments released from the cell wall of bacteria as part of their metabolism or as a result of biological stresses. These compounds trigger immune responses in mammals and plants. In bacteria, they play a major role in the induction of antibiotic resistance. In order to better understand these processes, we developed a new synthetic approach which combines synthetic biology and glycochemistry to prepare Gram (–) and Gram (+) muropeptides.
Hijacking the Peptidoglycan Recycling Pathway of Escherichia coli to Produce Muropeptides, A. Rousseau, J. Michaud, S. Pradeau, S. Armand, S. Cottaz, E. Richard, S. Fort, Chem. Eur. J. 2022, doi.org/10.1002/chem.202202991